Orthotopic Animal Model

Platbio promotes independent & joint drug development through a global level of orthotopic Animal model service.

Creates a similar environment as the human body by injecting cancer cells into the same target organs of mice

Establish model similar with tumor tissues of actual patients through Interaction with the microscopic environments of tumors

Orthotopic Animal Model
  • Subcutaneous Tissue
  • Low
  • X
  • X
Comparison item
  • Spread of generated area
    to other organs
  • Clinical recreation success rate
  • Cause spread to same organ
  • Interaction with surrounding tissue
Orthotopic Animal Model
  • Same organ
  • High
  • O
  • O

IN VIVO Anti-cancer Effect Unlike the ectopic animal model, cell inhibitory activity and apoptosis efficacy were verified in various solid cancer cell lines

In the case of the ectopic animal model, drug candidate B showed the largest decrease in tumor volume,
but in the orthotopic animal model, drug candidate A show the best result among 3 candidates.
Pancreatic cancer orthotopic model test results by PLATBIO

Ectopic Animal Model
Orthotopic Animal Model