PLATFORM
Orthotopic Animal Model
Platbio promotes independent & joint drug development through a global level of orthotopic Animal model service.
Creates a similar environment as the human body by injecting cancer cells into the same target organs of mice
Establish model similar with tumor tissues of actual patients through Interaction with the microscopic environments of tumors
- Orthotopic Animal Model
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- Subcutaneous Tissue
- Low
- X
- X
- Comparison item
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- Spread of generated area
to other organs - Clinical recreation success rate
- Cause spread to same organ
- Interaction with surrounding tissue
- Spread of generated area
- Orthotopic Animal Model
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- Same organ
- High
- O
- O
IN VIVO Anti-cancer Effect Unlike the ectopic animal model, cell inhibitory activity and apoptosis efficacy were verified in various solid cancer cell lines
In the case of the ectopic animal model, drug candidate B showed the largest decrease in tumor volume,
but in the orthotopic animal model, drug candidate A show the best result among 3 candidates.
Pancreatic cancer orthotopic model test results by PLATBIO
- Ectopic Animal Model
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- Orthotopic Animal Model
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